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REC-7735 is an experimental small molecule, mutant-selective PI3K-alpha inhibitor from Recursion Pharmaceuticals, in phase 1 trials for HR-positive / HER2-negative breast cancer with PIK3CA H1047R and solid tumours.
REC-7735 is a small molecule, mutant-selective PI3K-alpha inhibitor from Recursion Pharmaceuticals. A PI3K-alpha H1047R mutant-selective inhibitor, designed to avoid the dose-limiting high blood sugar seen with inhibitors of normal (wild-type) PI3K-alpha. Its furthest stage is phase 1, for HR-positive / HER2-negative breast cancer with PIK3CA H1047R and solid tumours. ClinicalTrials.gov registers it in one study linked below. Pipeline page: 'Status: Phase 1'. Registry NCT07819136 (phase 1/2) recruiting. Whether it works in people has not been established unless a trial below reports it.
A PI3K-alpha H1047R mutant-selective inhibitor, designed to avoid the dose-limiting high blood sugar seen with inhibitors of normal (wild-type) PI3K-alpha. Connects to PIK3CA / PI3K-alpha.
1.REC-7735 slips into a pocket on PIK3CA / PI3K-alpha.
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Query for this drug: (TITLE:"REC-7735" OR ABSTRACT:"REC-7735") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about REC-7735, not a curated reading list.
Shares Recursion Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares PIK3CA / PI3K-alpha, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Recursion Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Recursion Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares PIK3CA / PI3K-alpha, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Recursion Pharmaceuticals and the tag pipeline.
Shares Recursion Pharmaceuticals and the tag pipeline.
Shares Recursion Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
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