Tissue factor
Tissue factor is a clotting protein that cancers abnormally display on their surface, used as an ADC target in cervical cancer. This dossier gathers the 1 product (1 approved), 1 trial, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Initiates the extrinsic coagulation cascade; tumour expression drives thrombosis and angiogenesis.
- Cervical
- Pancreatic
- Head and neck
- Ovarian
Elsewhere: identifiers and databases
Built from HGNC, Ensembl, UniProt and ChEMBL idsHow common it is, by cancer
Full matrix →| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Cervical cancer | 90-95% | IHC, any expression | innovaTV did not select on TF | Wikipedia |
| Pancreatic ductal adenocarcinoma | 50-80% | IHC, any expression | Wikipedia |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Products by modality and phase
Browse products →| Modality | Approved |
|---|---|
| ADC 1 |
Trials
Evidence ranking →| Trial | Phase | Status | Setting | Result | Products |
|---|---|---|---|---|---|
| innovaTV 301 / ENGOT-cx12 / GOG-3057 NCT04697628 | 3 | Positive | Recurrent or metastatic cervical cancer after 1-2 prior lines including platinum: tisotumab vedotin vs investigator's-choice chemotherapy | OS 11.5 vs 9.5 months (HR 0.70). |
Resistance routes that involve this target
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways where it is a node
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics and assays
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Ideas and companies
Key papers and the live literature
Preprints →Query for this target: (TITLE:"Tissue factor" OR ABSTRACT:"Tissue factor" OR TITLE:"F3" OR ABSTRACT:"F3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Tissue factor, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tissue-factor.json. Licence CC BY 4.0.