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AlphaPARP is an experimental radioactive drug from Trevarx Biomedical that carries an alpha-emitting atom to the DNA-repair enzyme PARP1 in cancer cells. It is being prepared for a first trial in ovarian cancer.
AlphaPARP ([211At]PTT) is Trevarx Biomedical's first therapeutic. The company states that its effect comes from DNA-proximal alpha energy deposition rather than from PARP inhibition itself. A 2026 National Cancer Institute SBIR award funds IND-enabling work for a phase 1 study in ovarian cancer, with a fluorine-18 companion imaging agent for patient selection. No registered trial was found.
Astatine-211 covalently attached to a PARP inhibitor analogue (Parthanatine) that binds activated PARP1 at sites of tumour DNA damage, so the alpha particle is emitted beside the DNA and causes double-strand breaks, as described by Trevarx Biomedical. Connects to PARP.
1.AlphaPARP binds PARP on the cancer cell or is taken up by it.
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Query for this drug: (TITLE:"AlphaPARP" OR ABSTRACT:"AlphaPARP" OR TITLE:"[211At]PTT" OR ABSTRACT:"[211At]PTT" OR TITLE:"211At-Parthanatine" OR ABSTRACT:"211At-Parthanatine" OR TITLE:"Astatine-211 parthanatine" OR ABSTRACT:"Astatine-211 parthanatine") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AlphaPARP, not a curated reading list.
Shares Targeted alpha therapy and the tag pipeline.
Shares PARP and the tag pipeline.
Shares Targeted alpha therapy and the tag pipeline.
Shares PARP and the tag pipeline.
Shares PARP and the tag pipeline.
Shares PARP and the tag pipeline.
Shares PARP and the tag pipeline.
Shares PARP and the tag pipeline.
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