AZD0486
AZD0486 is an experimental bispecific antibody from AstraZeneca in phase 3 trials for diffuse large B-cell lymphoma, aimed at CD19 and CD3.
Overview
AZD0486 (TNB-486) is a bispecific antibody developed by AstraZeneca. Its targets are CD19 and CD3 (the sponsor names CD19 x CD3). It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT07215585 (AZD0486 1L Therapy for Elderly or Unfit Participants With LBCL), in diffuse large B-cell lymphoma. The largest, NCT07215585, plans to enrol 420 participants with primary completion expected 2030-06-10. Status reflects the highest phase registered on ClinicalTrials.gov at the 2026-09-11 check; no efficacy results are recorded here.
Trials
topTrials recruiting now
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Landmark trials
Latest papers
topQuery for this drug: (TITLE:"AZD0486" OR ABSTRACT:"AZD0486" OR TITLE:"TNB-486" OR ABSTRACT:"TNB-486") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AZD0486, not a curated reading list.
Similar pages
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Shares CD19, Diffuse large B-cell lymphoma and the tags pipeline, ctgov-ingest.
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Shares CD3 and the tags pipeline, ctgov-ingest.