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Tozuleristide is an experimental fluorescent imaging agent from Blaze Bioscience, in phase 3 trials for paediatric central nervous system tumours, breast cancer and glioma and other cancers.
Tozuleristide (BLZ-100, Tumor Paint) is a fluorescent imaging agent (chlorotoxin-derived peptide conjugated to a near-infrared dye) from Blaze Bioscience. An investigational intraoperative imaging agent whose active component is a chlorotoxin-variant cystine-dense mini-protein conjugated to a near-infrared fluorescent dye; it is taken up and retained by cancer cells so tumour tissue fluoresces under near-infrared imaging during surgery. Its furthest stage is phase 3, for paediatric central nervous system tumours, breast cancer, glioma and skin cancer. ClinicalTrials.gov registers it in 8 studies linked below. Phase 2/3 paediatric CNS trial NCT03579602 completed; FDA Fast Track for paediatric CNS tumours; company now names breast cancer (breast-conserving surgery) as lead indication with an investigator-sponsored trial planned. Whether it works in people has not been established unless a trial below reports it.
An investigational intraoperative imaging agent whose active component is a chlorotoxin-variant cystine-dense mini-protein conjugated to a near-infrared fluorescent dye; it is taken up and retained by cancer cells so tumour tissue fluoresces under near-infrared imaging during surgery.
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Query for this drug: (TITLE:"Tozuleristide" OR ABSTRACT:"Tozuleristide" OR TITLE:"BLZ-100" OR ABSTRACT:"BLZ-100" OR TITLE:"Tumor Paint" OR ABSTRACT:"Tumor Paint") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Tozuleristide, not a curated reading list.
Shares Sarcomas (soft tissue, bone, GIST), Head and neck squamous cell carcinoma, Breast cancer (all types) and the tag pipeline.
Shares Brain and spinal cord tumours (all types), Sarcomas (soft tissue, bone, GIST) and the tag pipeline.
Shares Sarcomas (soft tissue, bone, GIST), Head and neck squamous cell carcinoma and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Breast cancer (all types) and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Breast cancer (all types) and the tag pipeline.
Shares Sarcomas (soft tissue, bone, GIST), Breast cancer (all types) and the tag pipeline.
Shares Sarcomas (soft tissue, bone, GIST), Head and neck squamous cell carcinoma and the tag pipeline.
Shares Brain and spinal cord tumours (all types) and the tag pipeline.
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