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CB-011 is an experimental allogeneic CAR-T cell therapy from Caribou Biosciences, in phase 1 trials for relapsed or refractory multiple myeloma.
CB-011 is an allogeneic CAR-T cell therapy (CRISPR Cas12a chRDNA genome-edited) from Caribou Biosciences. An allogeneic anti-BCMA CAR-T cell therapy made with four Cas12a chRDNA edits: TRAC knockout, a humanised anti-BCMA CAR inserted into TRAC, and a B2M-HLA-E fusion inserted into B2M that knocks out endogenous B2M, meant to blunt T and NK cell rejection by the patient's immune system. Its furthest stage is phase 1, for relapsed or refractory multiple myeloma. ClinicalTrials.gov registers it in one study linked below. Company calls it its second clinical-stage program; NCT05722418 (phase 1) recruiting. Whether it works in people has not been established unless a trial below reports it.
An allogeneic anti-BCMA CAR-T cell therapy made with four Cas12a chRDNA edits: TRAC knockout, a humanised anti-BCMA CAR inserted into TRAC, and a B2M-HLA-E fusion inserted into B2M that knocks out endogenous B2M, meant to blunt T and NK cell rejection by the patient's immune system. Connects to BCMA.
1.CB-011 slips into a pocket on BCMA.
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Query for this drug: (TITLE:"CB-011" OR ABSTRACT:"CB-011") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CB-011, not a curated reading list.
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Shares BCMA, Relapsed or refractory multiple myeloma and the tag pipeline.
Shares BCMA, Relapsed or refractory multiple myeloma and the tag pipeline.
Shares Caribou Biosciences and the tag pipeline.
Shares BCMA, Relapsed or refractory multiple myeloma and the tag pipeline.
Shares Relapsed or refractory multiple myeloma and the tag pipeline.
Shares Relapsed or refractory multiple myeloma and the tag pipeline.
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