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CR-001 is an experimental tetravalent bispecific antibody from Crescent Biopharma, in phase 2 trials for non-small cell lung cancer and advanced solid tumours.
CR-001 (SKB118) is a tetravalent bispecific antibody from Crescent Biopharma, with Sichuan Kelun-Biotech Biopharmaceutical as licensee (Greater China). A tetravalent bispecific antibody that blocks PD-1 and VEGF together; the company says it was designed to show the same cooperative pharmacology as ivonescimab, with PD-1 binding increased in the presence of VEGF. Its furthest stage is phase 2, for non-small cell lung cancer and advanced solid tumours. ClinicalTrials.gov registers it in 4 studies linked below. Global (ex-Greater China) phase 1/2 ASCEND trial recruiting; Kelun-Biotech runs phase 2 combination trials with sacituzumab tirumotecan in China under the name SKB118. Whether it works in people has not been established unless a trial below reports it.
A tetravalent bispecific antibody that blocks PD-1 and VEGF together; the company says it was designed to show the same cooperative pharmacology as ivonescimab, with PD-1 binding increased in the presence of VEGF. Connects to PD-1 and VEGF / VEGFR.
1.One arm of CR-001 binds PD-1 on the cancer cell.
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Query for this drug: (TITLE:"CR-001" OR ABSTRACT:"CR-001" OR TITLE:"SKB118" OR ABSTRACT:"SKB118") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CR-001, not a curated reading list.
Shares Crescent Biopharma, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Crescent Biopharma, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Sichuan Kelun-Biotech, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Sichuan Kelun-Biotech, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Sichuan Kelun-Biotech, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Sichuan Kelun-Biotech, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Sichuan Kelun-Biotech, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Sichuan Kelun-Biotech, Metastatic cancer (cancer that has spread) and the tag pipeline.
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