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DMR-001 is an experimental monoclonal antibody from Damora Therapeutics, in phase 1 trials for CALR-mutant essential thrombocythaemia and CALR-mutant myelofibrosis.
DMR-001 is a monoclonal antibody (subcutaneous, half-life extended) from Damora Therapeutics. An antibody designed to bind only mutant calreticulin (mutCALR), the driver of some myeloproliferative neoplasms, with half-life extension intended to allow infrequent subcutaneous dosing. Its furthest stage is phase 1, for CALR-mutant essential thrombocythaemia and CALR-mutant myelofibrosis. ClinicalTrials.gov registers it in one study linked below. Global phase 1/1b CLARITY-101 started mid-2026 (NCT07849231, recruiting). Whether it works in people has not been established unless a trial below reports it.
An antibody designed to bind only mutant calreticulin (mutCALR), the driver of some myeloproliferative neoplasms, with half-life extension intended to allow infrequent subcutaneous dosing. Connects to CALR.
1.DMR-001 binds CALR.
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Query for this drug: (TITLE:"DMR-001" OR ABSTRACT:"DMR-001") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DMR-001, not a curated reading list.
Shares Essential thrombocythaemia (ET), Primary myelofibrosis and the tag pipeline.
Shares Primary myelofibrosis and the tag pipeline.
Shares Primary myelofibrosis and the tag pipeline.
Shares Essential thrombocythaemia (ET) and the tag pipeline.
Shares Essential thrombocythaemia (ET) and the tag pipeline.
Shares Essential thrombocythaemia (ET) and the tag pipeline.
Shares Essential thrombocythaemia (ET) and the tag pipeline.
Shares Primary myelofibrosis and the tag pipeline.
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