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DT-7012 is an experimental monoclonal antibody from Domain Therapeutics, in phase 2 trials for advanced solid tumours, cutaneous T-cell lymphoma and soft tissue sarcoma.
DT-7012 is a monoclonal antibody (depleting) from Domain Therapeutics. An anti-CCR8 antibody designed to remove highly immunosuppressive regulatory T cells from tumours through ADCC and ADCP. Its furthest stage is phase 2, for advanced solid tumours, cutaneous T-cell lymphoma and soft tissue sarcoma (undifferentiated pleomorphic sarcoma, dedifferentiated liposarcoma). ClinicalTrials.gov registers it in 3 studies linked below. Phase 1/2 DOMISOL (NCT06819735) recruiting; investigator trials in CTCL (NCT07213882, APHP) and soft tissue sarcoma (NCT07802652, Gustave Roussy, phase 2) not yet recruiting. Whether it works in people has not been established unless a trial below reports it.
An anti-CCR8 antibody designed to remove highly immunosuppressive regulatory T cells from tumours through ADCC and ADCP.
1.DT-7012 binds its target.
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Query for this drug: (TITLE:"DT-7012" OR ABSTRACT:"DT-7012") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DT-7012, not a curated reading list.
Shares Kainova Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Kainova Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Sarcomas (soft tissue, bone, GIST), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome) and the tag pipeline.
Shares Sarcomas (soft tissue, bone, GIST), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Sarcomas (soft tissue, bone, GIST), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome) and the tag pipeline.
Shares Sarcomas (soft tissue, bone, GIST) and the tag pipeline.
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