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BT-001 is an experimental oncolytic virus encoding an anti-CTLA-4 antibody and GM-CSF from BioInvent International, in phase 2 trials for metastatic solid tumours, melanoma and soft tissue sarcoma and other cancers; its current status is not stated.
BT-001 is an oncolytic virus (vaccinia) encoding an anti-CTLA-4 antibody and GM-CSF from BioInvent International, with Transgene as partner. An oncolytic virus built on Transgene's Invir.IO platform that encodes a Treg-depleting anti-CTLA-4 antibody from BioInvent and human GM-CSF, releasing the antibody locally in the tumour. Its furthest stage is phase 2, for metastatic solid tumours, melanoma, soft tissue sarcoma and merkel cell carcinoma. ClinicalTrials.gov registers it in one study linked below. Registry record NCT04725331 (lead sponsor Transgene, BioInvent and MSD collaborators) shows TERMINATED, while BioInvent's programme page still says 'Clinical phase 1/2a study (NCT04725331) ongoing'. Conflict; do not call it active. Whether it works in people has not been established unless a trial below reports it.
An oncolytic virus built on Transgene's Invir.IO platform that encodes a Treg-depleting anti-CTLA-4 antibody from BioInvent and human GM-CSF, releasing the antibody locally in the tumour. Connects to CTLA-4.
1.BT-001 binds CTLA-4.
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Query for this drug: (TITLE:"BT-001" OR ABSTRACT:"BT-001") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BT-001, not a curated reading list.
Shares Transgene, CTLA-4, Non-small-cell lung cancer and the tag pipeline.
Shares BioInvent International, Melanoma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares BioInvent International, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Merkel cell carcinoma, Sarcomas (soft tissue, bone, GIST), Non-small-cell lung cancer and the tag pipeline.
Shares Transgene, Non-small-cell lung cancer and the tag pipeline.
Shares BioInvent International, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Transgene and the tag pipeline.
Shares Sarcomas (soft tissue, bone, GIST), Triple-negative breast cancer (TNBC), Non-small-cell lung cancer and the tag pipeline.
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