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TG6050 is an experimental oncolytic virus, intravenous from Transgene, in phase 1 trials for metastatic non-small cell lung cancer; its current status is not stated.
TG6050 is an oncolytic virus (vaccinia, Invir.IO platform), intravenous from Transgene. An oncolytic virus engineered to make human IL-12 and a full-length anti-CTLA-4 antibody inside the tumour. Its furthest stage is phase 1, for metastatic non-small cell lung cancer. ClinicalTrials.gov registers it in one study linked below. Phase 1 Delivir trial NCT05788926 in metastatic NSCLC was terminated ('Sponsor decision not related to safety', registry updated July 2025). Transgene's site still lists TG6050 in its pipeline menu; no source read says it is discontinued. Whether it works in people has not been established unless a trial below reports it.
An oncolytic virus engineered to make human IL-12 and a full-length anti-CTLA-4 antibody inside the tumour. Connects to CTLA-4.
1.TG6050 slips into a pocket on CTLA-4.
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Query for this drug: (TITLE:"TG6050" OR ABSTRACT:"TG6050") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TG6050, not a curated reading list.
Shares Transgene and the tag pipeline.
Shares Transgene, CTLA-4, Non-small-cell lung cancer and the tag pipeline.
Shares Transgene and the tag pipeline.
Shares Transgene and the tag pipeline.
Shares Transgene, Non-small-cell lung cancer and the tag pipeline.
Shares CTLA-4, Non-small-cell lung cancer and the tag pipeline.
Shares Transgene and the tag pipeline.
Shares Non-small-cell lung cancer and the tag pipeline.
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