Fulzerasib
Fulzerasib was the first KRAS G12C-blocking pill approved in China, for lung cancers carrying that mutation after earlier treatment.
Overview
Discovered by GenFleet Therapeutics and developed in China with Innovent, fulzerasib was approved by the NMPA in August 2024 for KRAS G12C-mutant advanced NSCLC after at least one systemic therapy, on a pivotal single-arm phase 2 study (Journal of Thoracic Oncology 2024) with a confirmed response rate near half of patients. It arrived three years after sotorasib in the US but within weeks of garsorasib, giving China two domestic KRAS G12C inhibitors before either Western drug was approved there. First-line combinations with cetuximab are in trials.
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Approvals
| Region | Year | Indication |
|---|---|---|
| China | 2024 | KRAS G12C-mutant advanced NSCLC after at least one systemic therapy |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Fulzerasib" OR ABSTRACT:"Fulzerasib" OR TITLE:"Dupert" OR ABSTRACT:"Dupert" OR TITLE:"GFH925" OR ABSTRACT:"GFH925" OR TITLE:"IBI351" OR ABSTRACT:"IBI351") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Fulzerasib, not a curated reading list.
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