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An experimental antibody drug that carries two cancer-killing payloads to cells carrying TROP2. A first human study is registered but is still listed as not yet recruiting in an older record.
KH815 is a TROP2-directed dual-payload ADC from Chengdu Kanghong Biotech. AACR 2025 abstract 1586 describes TOP1 and RNA polymerase II inhibitor payloads and preclinical tumor-model and non-GLP primate findings; those findings do not establish human safety or comparative benefit. Its registered phase 1 study NCT06885645 plans 30 participants with advanced solid tumors. The record last posted 3 April 2025 still says NOT_YET_RECRUITING when checked 6 October 2026, with an estimated start of 30 April 2025 and no posted results. Registration and a past estimated start do not establish that dosing has begun; current recruitment requires sponsor confirmation.
A humanized TROP2-directed hRS7 antibody delivers a topoisomerase I inhibitor and an RNA polymerase II inhibitor. The two payload classes act on DNA damage and RNA synthesis, respectively. Connects to TROP2.
1.KH815's antibody arm binds TROP2 on the surface of the cancer cell.
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Query for this drug: (TITLE:"KH815" OR ABSTRACT:"KH815") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KH815, not a curated reading list.
Shares Dual-payload ADC, TROP2, Antibody-drug conjugate (ADC) and the tags pipeline, dual-payload.
Shares Dual-payload ADC, TROP2, Antibody-drug conjugate (ADC).
Shares Dual-payload ADC, TROP2, Antibody-drug conjugate (ADC).
Shares Dual-payload ADC, TROP2, Antibody-drug conjugate (ADC).
Shares Dual-payload ADC, TROP2, Antibody-drug conjugate (ADC).
Shares Dual-payload ADC, TROP2, Antibody-drug conjugate (ADC) and the tag pipeline.
Shares TROP2, Antibody-drug conjugate (ADC) and the tag pipeline.
Shares TROP2, Antibody-drug conjugate (ADC) and the tag pipeline.
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