Loading
NEO-811 is an experimental molecular glue degrader from Neomorph, in phase 1 trials for clear cell renal cell carcinoma.
NEO-811 (NEO811) is a molecular glue degrader (cereblon-dependent) from Neomorph. An investigational molecular glue degrader designed to induce targeted degradation of a key disease-driving protein and fully block a central signalling pathway in clear cell renal cell carcinoma; the pipeline page names the target as ARNT/HIF-1beta. Its furthest stage is phase 1, for clear cell renal cell carcinoma. ClinicalTrials.gov registers it in one study linked below. First patient dosed in phase 1/2 NEO-811-101 (NCT07300241), announced 3 Feb 2026; registry lists PHASE1, recruiting. Whether it works in people has not been established unless a trial below reports it.
An investigational molecular glue degrader designed to induce targeted degradation of a key disease-driving protein and fully block a central signalling pathway in clear cell renal cell carcinoma; the pipeline page names the target as ARNT/HIF-1beta. Connects to ARNT.
1.NEO-811 binds ARNT with one end and an E3 ubiquitin ligase with the other.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"NEO-811" OR ABSTRACT:"NEO-811" OR TITLE:"NEO811" OR ABSTRACT:"NEO811") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NEO-811, not a curated reading list.
Shares Clear cell renal cell carcinoma and the tag pipeline.
Shares Clear cell renal cell carcinoma and the tag pipeline.
Shares Clear cell renal cell carcinoma and the tag pipeline.
Shares Clear cell renal cell carcinoma and the tag pipeline.
Shares Clear cell renal cell carcinoma and the tag pipeline.
Shares Clear cell renal cell carcinoma and the tag pipeline.
Shares Clear cell renal cell carcinoma and the tag pipeline.
Shares Clear cell renal cell carcinoma and the tag pipeline.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/