Netupitant and palonosetron
Akynzeo combines two anti-sickness drugs in one capsule or infusion taken once before chemotherapy, so a single dose plus dexamethasone protects against both immediate and delayed vomiting.
Overview
Netupitant/palonosetron was approved by the FDA in October 2014 for prevention of acute and delayed nausea and vomiting with initial and repeat courses of chemotherapy including highly emetogenic regimens, in combination with dexamethasone, on phase 3 trials against palonosetron alone in cisplatin and anthracycline-cyclophosphamide regimens in which complete response over five days was significantly higher; the intravenous fosnetupitant/palonosetron formulation followed in 2018. The EU authorised Akynzeo in 2015. It simplifies the guideline-recommended triple regimen to one antiemetic product plus a steroid. Headache, asthenia and constipation are the main adverse effects; netupitant is a moderate CYP3A4 inhibitor.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2014 | Acute and delayed chemotherapy-induced nausea and vomiting including highly emetogenic regimens, with dexamethasone (intravenous form 2018) |
| EU | 2015 | Acute and delayed nausea and vomiting with highly and moderately emetogenic chemotherapy (Akynzeo) |
Trials
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Latest papers
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