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Cyclizine is an anti-sickness tablet or injection widely used in the UK, including for sickness caused by opioid painkillers and by radiotherapy.
The UK SmPCs list prevention and treatment of nausea and vomiting from motion sickness, from narcotic analgesics and general anaesthetics after surgery, and "vomiting associated with radiotherapy especially for breast cancer since Cyclizine does not elevate prolactin levels". The Scottish Palliative Care Guidelines advise against prescribing a prokinetic such as metoclopramide together with an anticholinergic such as cyclizine, because the anticholinergic diminishes the prokinetic effect. It is not marketed as a prescription medicine in the US.
A histamine H1 receptor antagonist of the piperazine class with anticholinergic and antiemetic properties (UK SmPC 5.1).
1.Cyclizine slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| UK | 2001 | Prevention and treatment of nausea and vomiting: motion sickness, narcotic analgesics and general anaesthetics after surgery, and vomiting with radiotherapy, especially for breast cancer · Year is the first authorisation of UK licence PL 20072/0241 (tablets) as printed in its SmPC, not the first approval of the medicine |
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Query for this drug: (TITLE:"Cyclizine" OR ABSTRACT:"Cyclizine" OR TITLE:"Valoid" OR ABSTRACT:"Valoid") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cyclizine, not a curated reading list.
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Shares Metoclopramide, Antiemetics for chemotherapy-induced nausea and vomiting and the tag supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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