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Levomepromazine is a strong anti-sickness and calming medicine used in hospices and palliative care, often by a small pump under the skin, for nausea, restlessness and distress near the end of life.
The UK SmPC for the injection gives "management of the terminally ill patient" and "the management of pain and accompanying restlessness or distress in the terminally ill patient"; the tablets add psychiatric uses. MASCC/ESMO 2016 lists it as an alternative to metoclopramide for nausea and vomiting in advanced cancer. In the EAPC 2024 framework for palliative sedation it is the step 2 medicine, added to midazolam when midazolam alone is not enough. It is not marketed in the US.
Resembles chlorpromazine and promethazine: anti-emetic, antihistamine and anti-adrenaline activity with a strong sedative effect (UK SmPC 5.1).
1.Levomepromazine slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| UK | 2012 | Injection: management of pain and accompanying restlessness or distress in the terminally ill patient · Year is the first authorisation of UK licence PL 29831/0462 as printed in its SmPC, not the first approval of the medicine |
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Query for this drug: (TITLE:"Levomepromazine" OR ABSTRACT:"Levomepromazine" OR TITLE:"Nozinan" OR ABSTRACT:"Nozinan" OR TITLE:"methotrimeprazine" OR ABSTRACT:"methotrimeprazine") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Levomepromazine, not a curated reading list.
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Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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