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Anakinra is an anti-inflammatory injection approved for arthritis and rare inflammatory diseases. After CAR-T cell therapy it is used to calm a severe inflammatory reaction (IEC-HS) and as a third-line option when cytokine release syndrome does not settle.
The Kineret label covers rheumatoid arthritis, neonatal-onset multisystem inflammatory disease (a cryopyrin-associated periodic syndrome) and deficiency of the interleukin-1 receptor antagonist. In the ASTCT consensus on immune effector cell-associated HLH-like syndrome (Hines 2023), "Anakinra was recommended as a first-line agent", and "Therapy should generally be initiated with corticosteroids +/− anakinra prior to development of life-threatening complications". SITC 2020 says that if cytokine release syndrome does not improve after two doses of tocilizumab and steroids, third-line agents including anakinra, siltuximab and high-dose methylprednisolone should be considered (level of evidence 4). Its use in these settings is off-label. The BLA was first approved on 14 November 2001.
A recombinant interleukin-1 receptor antagonist that blocks IL-1 signalling.
1.Anakinra binds its target.
| Region | Year | Indication |
|---|---|---|
| US | 2001 | Rheumatoid arthritis; neonatal-onset multisystem inflammatory disease; deficiency of interleukin-1 receptor antagonist · Year is the original BLA 103950 approval (Drugs@FDA); oncology use is off-label |
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Query for this drug: (TITLE:"Anakinra" OR ABSTRACT:"Anakinra" OR TITLE:"Kineret" OR ABSTRACT:"Kineret") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Anakinra, not a curated reading list.
Shares CAR-T cell therapy and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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