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Apixaban is a blood-thinning tablet. Guidelines now accept it for treating a clot in most people with cancer, and for preventing clots in some people starting chemotherapy who are at higher risk.
The Eliquis label covers stroke prevention in non-valvular atrial fibrillation, DVT prophylaxis after hip or knee replacement, and treatment of DVT and pulmonary embolism with reduction of recurrence. ITAC 2022: rivaroxaban or apixaban can be used for initial treatment of established VTE in people with cancer without a high risk of gastrointestinal or genitourinary bleeding (1A), DOACs are recommended for maintenance in the absence of strong drug interactions or impaired absorption, with caution in gastrointestinal cancers (1A), and rivaroxaban or apixaban are recommended as primary prophylaxis for ambulatory people on systemic anticancer therapy with a Khorana score of 2 or more and low bleeding risk (1B), including those with locally advanced or metastatic pancreatic cancer (1B). The 2023 ASCO update added apixaban as an option for treating VTE (strong recommendation, high-quality evidence) and, with rivaroxaban, for extended prophylaxis after cancer surgery (weak). The NDA was first approved on 28 December 2012.
A direct, oral inhibitor of activated factor X.
1.Apixaban slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 2012 | Stroke prevention in non-valvular atrial fibrillation; DVT prophylaxis after hip or knee replacement; treatment of DVT and PE and reduction of recurrence · Year is the original NDA 202155 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Apixaban" OR ABSTRACT:"Apixaban" OR TITLE:"Eliquis" OR ABSTRACT:"Eliquis") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Apixaban, not a curated reading list.
Shares Dalteparin, Enoxaparin, Venous thromboembolism (VTE), Cancer-associated thrombosis prevention and treatment and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Enoxaparin, Venous thromboembolism (VTE), Cancer-associated thrombosis prevention and treatment and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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