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Rivaroxaban is a blood-thinning tablet used to treat a clot in many people with cancer, and to prevent clots in some people starting chemotherapy who are at higher risk.
The Xarelto label covers atrial fibrillation, treatment of DVT and pulmonary embolism and reduction of recurrence, prophylaxis after hip or knee replacement and in acutely ill medical patients, and coronary and peripheral artery disease. ITAC 2022 accepts rivaroxaban for initial and maintenance treatment of VTE in people with cancer without a high risk of gastrointestinal or genitourinary bleeding (1A), and recommends rivaroxaban or apixaban for primary prophylaxis in ambulatory people on systemic anticancer therapy with a Khorana score of 2 or more (1B), including locally advanced or metastatic pancreatic cancer (1B). The 2023 ASCO update added rivaroxaban and apixaban as options for extended prophylaxis after cancer surgery (weak recommendation). The NDA was first approved on 1 July 2011.
A direct, oral inhibitor of activated factor X.
1.Rivaroxaban slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 2011 | Atrial fibrillation; treatment of DVT and PE and reduction of recurrence; VTE prophylaxis after hip or knee replacement and in acutely ill medical patients; coronary and peripheral artery disease · Year is the original NDA 022406 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Rivaroxaban" OR ABSTRACT:"Rivaroxaban" OR TITLE:"Xarelto" OR ABSTRACT:"Xarelto") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Rivaroxaban, not a curated reading list.
Shares Apixaban, Enoxaparin, Venous thromboembolism (VTE), Cancer-associated thrombosis prevention and treatment and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Enoxaparin, Venous thromboembolism (VTE), Cancer-associated thrombosis prevention and treatment and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Enoxaparin, Venous thromboembolism (VTE), Cancer-associated thrombosis prevention and treatment and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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