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Doxycycline is an antibiotic tablet. People starting EGFR-blocking cancer drugs often take it for the first weeks to make the acne-like rash milder.
The US label covers a long list of bacterial infections. The MASCC EGFR inhibitor guideline (2011) states: "Hydrocortisone 1% combined with moisturizer, sunscreen, and doxycycline 100 mg bid for the first 6 weeks is recommended based on randomized data", and notes that doxycycline appears safer with renal dysfunction while minocycline is less photosensitising. The amivantamab (Rybrevant) label tells prescribers to give an oral antibiotic, "doxycycline or minocycline, 100 mg orally twice daily", from day 1 for the first 12 weeks. The Vibramycin NDA was approved on 5 December 1967.
A tetracycline-class antibacterial; in acneiform rash it is used for its anti-inflammatory effect as well as against bacteria.
1.Doxycycline slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1967 | Bacterial infections including rickettsial, respiratory, urinary and sexually transmitted infections, and others listed on the label · Year is the Vibramycin NDA 050007 approval (Drugs@FDA); rash prophylaxis is off-label except as directed in the amivantamab label |
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Query for this drug: (TITLE:"Doxycycline" OR ABSTRACT:"Doxycycline" OR TITLE:"Vibramycin" OR ABSTRACT:"Vibramycin" OR TITLE:"Doryx" OR ABSTRACT:"Doryx") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Doxycycline, not a curated reading list.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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