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Dalteparin is a daily blood-thinning injection. Its US label is one of the few written for people with cancer: it treats a clot and keeps giving protection for six months so that another clot is less likely.
The Fragmin label includes "extended treatment of symptomatic venous thromboembolism (VTE) to reduce the recurrence in adult patients with cancer", the therapy beginning with the initial treatment and continuing for six months, alongside DVT prophylaxis in surgery and in medical patients and the prevention of ischaemic complications of unstable angina. ITAC 2022 recommends LMWH for initial treatment and prefers LMWHs over vitamin K antagonists; dalteparin is the comparator in several of the trials ITAC weighs, including ADAM-VTE, where apixaban was compared with dalteparin. The NDA was first approved on 22 December 1994.
A low-molecular-weight heparin: potentiates antithrombin, mainly against activated factor X.
1.Dalteparin slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1994 | Extended treatment of symptomatic VTE to reduce recurrence in adults with cancer (six months); DVT prophylaxis; unstable angina; VTE in children · Year is the original NDA 020287 approval (Drugs@FDA); the cancer indication came later |
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Query for this drug: (TITLE:"Dalteparin" OR ABSTRACT:"Dalteparin" OR TITLE:"Fragmin" OR ABSTRACT:"Fragmin" OR TITLE:"dalteparin sodium" OR ABSTRACT:"dalteparin sodium") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Dalteparin, not a curated reading list.
Shares Tinzaparin, Enoxaparin, Venous thromboembolism (VTE), Cancer-associated thrombosis prevention and treatment and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Apixaban, Enoxaparin, Venous thromboembolism (VTE), Cancer-associated thrombosis prevention and treatment and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Apixaban, Enoxaparin, Venous thromboembolism (VTE), Cancer-associated thrombosis prevention and treatment and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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