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Duloxetine is a capsule for depression and nerve pain. It is the one medicine with good enough evidence to recommend for painful nerve damage caused by chemotherapy, though its benefit is modest.
The US label covers major depressive disorder, generalised anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia and chronic musculoskeletal pain. ASCO's 2020 CIPN guideline: "Duloxetine is the only agent that has appropriate evidence to support its use for patients with established painful CIPN. Nonetheless, the amount of benefit from duloxetine is limited." The Japan Society of Pain Clinicians weakly recommends it for chronic pain in survivors, being more effective for pain from chemotherapy-induced peripheral neuropathy than other adjuvant analgesics [2B]. A trial is testing whether it prevents oxaliplatin neuropathy in colorectal cancer. The Cymbalta NDA was approved on 3 August 2004.
Inhibits reuptake of serotonin and noradrenaline.
1.Duloxetine slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 2004 | Major depressive disorder; generalised anxiety disorder; diabetic peripheral neuropathic pain; fibromyalgia; chronic musculoskeletal pain · Year is the Cymbalta NDA 021427 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Duloxetine" OR ABSTRACT:"Duloxetine" OR TITLE:"Cymbalta" OR ABSTRACT:"Cymbalta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Duloxetine, not a curated reading list.
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Shares Cancer pain management and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Gabapentin and the tags generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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