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Gabapentin is a tablet for nerve pain and epilepsy. In cancer care it is used for nerve pain caused by the cancer or its treatment, and sometimes for hot flushes.
The Neurontin label covers postherpetic neuralgia and adjunctive treatment of partial-onset seizures. The Japan Society of Pain Clinicians (2025) weakly recommends gabapentinoids for neuropathic pain directly related to cancer in survivors because they can reduce the opioid dose needed [2B]. SITC 2021 says people with painful peripheral neuropathy from checkpoint inhibitors "should receive neuropathic pain medication such as gabapentin, pregabalin, or duloxetine until neuropathy resolves". Cancer Care Ontario lists gabapentin among non-hormonal options for hot flushes in women and men with cancer. The NDA was first approved on 30 December 1993.
Binds the alpha-2-delta subunit of voltage-activated calcium channels; the label states that the precise mechanism of its analgesic and antiepileptic actions is unknown.
1.Gabapentin slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1993 | Postherpetic neuralgia; adjunctive treatment of partial-onset seizures · Year is the Neurontin NDA 020235 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Gabapentin" OR ABSTRACT:"Gabapentin" OR TITLE:"Neurontin" OR ABSTRACT:"Neurontin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Gabapentin, not a curated reading list.
Shares Cancer pain management and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Cancer pain management and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Immune-related adverse events (irAEs) and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Immune-related adverse events (irAEs) and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Immune-related adverse events (irAEs) and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Cancer pain management and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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