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Infliximab is an anti-inflammatory drip used for Crohn's disease and arthritis. When checkpoint immunotherapy causes colitis that steroids do not control, it is the usual next step; it is avoided for immune hepatitis.
The Remicade label covers Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and plaque psoriasis. SITC 2021: if colitis does not respond to corticosteroids within 3 to 5 days, recurs on the taper, or is severely ulcerative at colonoscopy, "3 doses of infliximab (5 mg/kg) should be administered at 0, 2, and 6 weeks" (LE 1); people should be tested for hepatitis B, HIV and tuberculosis first without delaying the dose; and "Infliximab should not be used in patients with liver toxicity, given the risk for hepatotoxicity". SITC also names it for steroid-refractory nephritis and pneumonitis. The BLA was first approved on 24 August 1998.
A chimeric monoclonal antibody that binds and blocks tumour necrosis factor alpha.
1.Infliximab binds its target.
| Region | Year | Indication |
|---|---|---|
| US | 1998 | Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis · Year is the original BLA 103772 approval (Drugs@FDA); immune-related colitis is off-label |
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Query for this drug: (TITLE:"Infliximab" OR ABSTRACT:"Infliximab" OR TITLE:"Remicade" OR ABSTRACT:"Remicade") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Infliximab, not a curated reading list.
Shares Immune-related adverse events (irAEs) and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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