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Vedolizumab is a gut-targeted anti-inflammatory drip for ulcerative colitis and Crohn's disease, used when colitis caused by checkpoint immunotherapy does not settle with steroids and infliximab.
The Entyvio label covers moderately to severely active ulcerative colitis and Crohn's disease in adults. SITC 2021: if colitis symptoms persist after the second infliximab dose, "the third dose should be held and 3 doses of vedolizumab (300 mg) should be administered at 0, 2, and 6 weeks" (LE 1); SITC notes that vedolizumab blocks alpha-4 beta-7 integrin, giving gut-selective anti-inflammatory activity. The use for immune-related colitis is off-label. The BLA was first approved on 20 May 2014.
A monoclonal antibody against alpha-4 beta-7 integrin that blocks immune cell traffic into the gut, giving a gut-selective anti-inflammatory effect.
1.Vedolizumab binds its target.
| Region | Year | Indication |
|---|---|---|
| US | 2014 | Moderately to severely active ulcerative colitis and Crohn's disease in adults · Year is the original BLA 125476 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Vedolizumab" OR ABSTRACT:"Vedolizumab" OR TITLE:"Entyvio" OR ABSTRACT:"Entyvio") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Vedolizumab, not a curated reading list.
Shares Infliximab, Immune-related adverse events (irAEs) and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Immune-related adverse events (irAEs) and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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