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Mycophenolate is a medicine that damps down the immune system, approved to stop transplanted organs being rejected. In cancer care it is used when immunotherapy side effects such as hepatitis or pneumonitis do not respond to steroids.
The CellCept label covers prophylaxis of organ rejection in kidney, heart or liver transplant recipients, with other immunosuppressants. SITC 2021: if liver tests do not improve to grade 1 or better within 10 to 14 days of steroids, or hepatitis recurs on the taper, mycophenolate mofetil may be given at 1 to 2 g a day in two divided doses (LE 4); it is one option when pneumonitis does not improve within 72 hours of high-dose steroids, and for interstitial nephritis that does not respond to glucocorticoids. These uses are off-label. The NDA was first approved on 3 May 1995.
An antimetabolite immunosuppressant; its active form, mycophenolic acid, limits lymphocyte proliferation.
1.Mycophenolate mofetil slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1995 | Prophylaxis of organ rejection in kidney, heart or liver transplant recipients · Year is the CellCept NDA 050722 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Mycophenolate mofetil" OR ABSTRACT:"Mycophenolate mofetil" OR TITLE:"CellCept" OR ABSTRACT:"CellCept" OR TITLE:"MMF" OR ABSTRACT:"MMF" OR TITLE:"mycophenolic acid" OR ABSTRACT:"mycophenolic acid") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Mycophenolate mofetil, not a curated reading list.
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Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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