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Cyproterone is a hormone tablet for prostate cancer, used in the UK to block the brief testosterone surge when hormone injections start, as a treatment when other options do not suit, and to ease hot flushes caused by hormone therapy.
The UK SmPC for Cyprostat covers management of prostatic cancer "(1) to suppress 'flare' with initial LHRH analogue therapy, (2) in long-term palliative treatment where LHRH analogues or surgery are contraindicated, not tolerated, or where oral therapy is preferred, and (3) in the treatment of hot flushes in patients under treatment with LHRH analogues or who have had orchidectomy". NICE NG131 says to consider cyproterone acetate (50 mg twice a day for 4 weeks) for troublesome hot flushes if medroxyprogesterone is not effective or not tolerated, and Cancer Care Ontario lists it among the options for men with vasomotor symptoms. It is not marketed in the US. Because one of its indications treats the cancer itself, it is not counted as a supportive medicine.
Blocks androgen action on the tumour directly and, through its progestogenic activity, lowers gonadotrophin release and so testicular androgen production (UK SmPC 5.1).
1.Cyproterone acetate acts on its target, the hormone receptor or the enzyme that makes the hormone.
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| Region | Year | Indication |
|---|---|---|
| UK | 2008 | Management of prostate cancer: suppression of flare with initial LHRH analogue therapy, long-term palliative treatment, and hot flushes under LHRH analogues or after orchidectomy · Year is the first authorisation printed in the SmPC for the current Cyprostat licence (PL 56734/0017), not the first approval of the medicine |
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Query for this drug: (TITLE:"Cyproterone acetate" OR ABSTRACT:"Cyproterone acetate" OR TITLE:"Cyprostat" OR ABSTRACT:"Cyprostat" OR TITLE:"Androcur" OR ABSTRACT:"Androcur") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cyproterone acetate, not a curated reading list.
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