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Naloxone reverses an opioid overdose. For people on strong painkillers for cancer, it is given in small repeated doses so that breathing recovers without bringing all the pain back.
The US injection label covers "the complete or partial reversal of opioid depression, including respiratory depression" and diagnosis of suspected acute opioid overdose. The Australian cancer pain guideline (2025) advises that if the respiratory rate is 8 a minute or less and the person cannot be roused, "use the appropriate dose of naloxone in frequent small doses with the aim to improve consciousness without worsening pain", diluting the ampoule to 10 mL. The same guideline suggests switching to oxycodone combined with naloxone for opioid constipation that does not respond to laxatives. The Narcan NDA was approved on 13 April 1971.
A competitive opioid receptor antagonist that reverses the effects of opioids.
1.Naloxone slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1971 | Complete or partial reversal of opioid depression; diagnosis of suspected acute opioid overdose · Year is the Narcan NDA 016636 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Naloxone" OR ABSTRACT:"Naloxone" OR TITLE:"Narcan" OR ABSTRACT:"Narcan" OR TITLE:"naloxone hydrochloride" OR ABSTRACT:"naloxone hydrochloride") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Naloxone, not a curated reading list.
Shares Cancer pain management and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Cancer pain management and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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