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Morphine is the standard strong painkiller for cancer pain. NICE advises starting with regular morphine by mouth, with extra quick-acting doses for pain that breaks through.
US morphine labels cover acute and chronic pain severe enough to need an opioid when alternatives are inadequate, with warnings on addiction, abuse and misuse. NICE CG140 for adults needing strong opioids in palliative care: start with regular oral sustained-release or immediate-release morphine, with immediate-release morphine for breakthrough pain; with normal kidney and liver function a typical starting dose is 20 mg to 30 mg of oral morphine a day (for example 10 mg to 15 mg sustained-release twice daily) plus 5 mg immediate-release rescue doses; and oral sustained-release morphine is the first-line maintenance treatment. MASCC/ISOO 2020 suggests topical morphine 0.2% mouthwash for mucositis pain in head and neck cancer during chemoradiotherapy. The MS Contin NDA was approved on 29 May 1987.
A full agonist at the mu-opioid receptor.
1.Morphine slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1987 | Pain severe enough to require an opioid analgesic when alternatives are inadequate · Year is the MS Contin NDA 019516 approval (Drugs@FDA); other morphine products are older |
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Query for this drug: (TITLE:"Morphine" OR ABSTRACT:"Morphine" OR TITLE:"MS Contin" OR ABSTRACT:"MS Contin" OR TITLE:"Oramorph" OR ABSTRACT:"Oramorph" OR TITLE:"Sevredol" OR ABSTRACT:"Sevredol" OR TITLE:"morphine sulfate" OR ABSTRACT:"morphine sulfate") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Morphine, not a curated reading list.
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Shares Early integrated palliative care and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Cancer pain management and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Early integrated palliative care and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Early integrated palliative care and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Early integrated palliative care and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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