Loading
Metoclopramide is an anti-sickness medicine that also helps the stomach empty. It is the usual first choice for ongoing nausea in advanced cancer, but it is avoided when the bowel is completely blocked.
The US injection label includes "the prophylaxis of vomiting associated with emetogenic cancer chemotherapy" as well as diabetic gastroparesis, postoperative nausea and vomiting, small bowel intubation and radiological examination; the oral forms cover reflux and gastroparesis, with therapy not to exceed 12 weeks. MASCC/ESMO 2016: "The drug of choice for managing N & V in advanced cancer is metoclopramide titrated to effect. Alternative options include haloperidol, levomepromazine, or olanzapine." MASCC 2022 suggests dopamine antagonist prokinetics may help in partial malignant bowel obstruction but should likely be avoided in complete obstruction because of the risk of perforation. The Reglan NDA was approved on 30 December 1980.
A dopamine antagonist that speeds stomach emptying and gut transit (prokinetic) and acts against nausea centrally.
1.Metoclopramide slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1980 | Injection: prophylaxis of vomiting with emetogenic cancer chemotherapy, postoperative nausea and vomiting, diabetic gastroparesis and procedural uses; oral: reflux and diabetic gastroparesis · Year is the Reglan NDA 017854 approval (Drugs@FDA) |
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"Metoclopramide" OR ABSTRACT:"Metoclopramide" OR TITLE:"Reglan" OR ABSTRACT:"Reglan" OR TITLE:"Maxolon" OR ABSTRACT:"Maxolon") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Metoclopramide, not a curated reading list.
Shares Haloperidol and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Levomepromazine and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Levomepromazine and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/