Orelabrutinib
Orelabrutinib is InnoCare's BTK-blocking pill for chronic lymphocytic leukaemia and mantle cell lymphoma, approved in China in 2020.
Overview
Approved by the NMPA in December 2020 for relapsed or refractory chronic lymphocytic leukaemia or small lymphocytic lymphoma and for relapsed or refractory mantle cell lymphoma, with relapsed or refractory marginal zone lymphoma added in 2023, the first approval for any BTK inhibitor in that disease. It competes with zanubrutinib and ibrutinib in China's NRDL and is being tested in primary central nervous system lymphoma and, outside oncology, in multiple sclerosis.
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Approvals
| Region | Year | Indication |
|---|---|---|
| China | 2020 | Relapsed or refractory CLL/SLL; relapsed or refractory mantle cell lymphoma |
| China | 2023 | Relapsed or refractory marginal zone lymphoma |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Orelabrutinib" OR ABSTRACT:"Orelabrutinib" OR TITLE:"Yinuokai" OR ABSTRACT:"Yinuokai" OR TITLE:"ICP-022" OR ABSTRACT:"ICP-022") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Orelabrutinib, not a curated reading list.
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