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Gas bubbles injected into a vein during a heart ultrasound to show the heart's pumping chamber more clearly when the ordinary picture is not good enough.
Lantheus' Definity (NDA 021064, first approved 31 July 2001) is indicated, after activation, "for use in adult and pediatric patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border". Its boxed warning reads "Serious cardiopulmonary reactions, including fatalities, have occurred uncommonly during or following perflutren-containing microsphere administration". In the European Union it is Luminity (EMEA/H/C/000654, authorised 20 September 2006). ATC V08DA04.
Lipid-shelled microbubbles of perflutren gas fill the heart chambers and reflect ultrasound, outlining the wall of the left ventricle.
| Region | Year | Indication |
|---|---|---|
| US | 2001 | Opacification of the left ventricle in patients with suboptimal echocardiograms · NDA 021064; Lantheus |
| EU | 2006 | Ultrasound contrast in suboptimal echocardiography · Luminity, authorised 20 Sep 2006; Lantheus EU |
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Query for this drug: (TITLE:"Perflutren lipid microspheres" OR ABSTRACT:"Perflutren lipid microspheres" OR TITLE:"ultrasound contrast" OR ABSTRACT:"ultrasound contrast" OR TITLE:"Definity" OR ABSTRACT:"Definity" OR TITLE:"perflutren" OR ABSTRACT:"perflutren" OR TITLE:"Definity RT" OR ABSTRACT:"Definity RT" OR TITLE:"Luminity" OR ABSTRACT:"Luminity") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Perflutren lipid microspheres (ultrasound contrast), not a curated reading list.
Shares Ultrasound contrast agents (microbubbles), Elastography and contrast-enhanced ultrasound, Ultrasound and the tags contrast-agents-gaps-2026-11, diagnostic.
Shares Ultrasound contrast agents (microbubbles), Elastography and contrast-enhanced ultrasound, Ultrasound and the tags contrast-agents-gaps-2026-11, diagnostic.
Shares the tags contrast-agents-gaps-2026-11, diagnostic.
Shares the tags contrast-agents-gaps-2026-11, diagnostic.
Shares the tags contrast-agents-gaps-2026-11, diagnostic.
Shares the tags contrast-agents-gaps-2026-11, diagnostic.
Shares the tags contrast-agents-gaps-2026-11, diagnostic.
Shares the tags contrast-agents-gaps-2026-11, diagnostic.
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