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PoMA sonodynamic therapy is an experimental drug and ultrasound treatment from Alpheus Medical, in phase 2 trials for glioblastoma.
PoMA sonodynamic therapy (PoMA) is a drug-device combination: oral 5-aminolevulinic acid activated by low-intensity defocused ultrasound (sonodynamic therapy) from Alpheus Medical. Oral 5-ALA is turned into protoporphyrin IX, which the company says builds up preferentially in malignant glioma cells; low-intensity ultrasound across the brain hemisphere then activates it to make reactive oxygen species that damage the tumour cells. A first-in-human study in recurrent high-grade glioma (NCT05362409, where the device is named CV01) is completed; a phase 2 with temozolomide in newly diagnosed glioblastoma (NCT07225621) and a phase 1 study NCT07862647 are recruiting.
Oral 5-ALA is turned into protoporphyrin IX, which the company says builds up preferentially in malignant glioma cells; low-intensity ultrasound across the brain hemisphere then activates it to make reactive oxygen species that damage the tumour cells.
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Query for this drug: (TITLE:"PoMA sonodynamic therapy" OR ABSTRACT:"PoMA sonodynamic therapy" OR TITLE:"PoMA" OR ABSTRACT:"PoMA" OR TITLE:"Porphyrin Metabolite Activation" OR ABSTRACT:"Porphyrin Metabolite Activation" OR TITLE:"5-ALA HCl + LIDU SDT" OR ABSTRACT:"5-ALA HCl + LIDU SDT") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PoMA sonodynamic therapy, not a curated reading list.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
Shares Glioma & glioblastoma and the tag pipeline.
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