Recombinant human endostatin
Endostar is Simcere's recombinant endostatin, approved in China in 2005 with chemotherapy for advanced non-small-cell lung cancer, one of the first angiogenesis inhibitors approved anywhere.
Overview
Recombinant human endostatin (Endostar) was developed in China and is marketed by Simcere in Nanjing. The NMPA (then the SFDA) approved it in September 2005 in combination with vinorelbine and cisplatin for advanced non-small-cell lung cancer, a year after bevacizumab's US approval. It remains widely used in China and is being tested with immunotherapy.
A recombinant form of endostatin, a fragment of collagen XVIII that stops the growth of new blood vessels a tumour needs.
1.Recombinant human endostatin slips into a pocket on its target.
Compare all products across the US, EU, UK, Japan, China and Australia →
Approvals
| Region | Year | Indication |
|---|---|---|
| CN | 2005 | Advanced non-small-cell lung cancer, with vinorelbine and cisplatin |
Trials
topTrials recruiting now
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Latest papers
topQuery for this drug: (TITLE:"Recombinant human endostatin" OR ABSTRACT:"Recombinant human endostatin" OR TITLE:"Endostar" OR ABSTRACT:"Endostar" OR TITLE:"rh-endostatin" OR ABSTRACT:"rh-endostatin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Recombinant human endostatin, not a curated reading list.
Similar pages
not linked directly; found by shared links- TreatmentGumarontinib
Shares Non-small-cell lung cancer and the tags china, nmpa-approved.
- TreatmentIruplinalkib
Shares Non-small-cell lung cancer and the tags china, nmpa-approved.
- TreatmentBenmelstobart
Shares the tags china, nmpa-approved.
- TreatmentFlumatinib
Shares the tags china, nmpa-approved.
- TreatmentH101 oncolytic adenovirus
Shares the tags china, nmpa-approved.
- TreatmentInetetamab
Shares the tags china, nmpa-approved.
- TreatmentIparomlimab and tuvonralimab
Shares the tags china, nmpa-approved.
- TreatmentLinperlisib
Shares the tags china, nmpa-approved.