Relmacabtagene autoleucel
Relma-cel was the first CAR-T therapy developed and made in China to be approved, for large B-cell lymphoma that has come back after two treatments.
Overview
Approved by the NMPA in September 2021 for relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, three months after the Fosun Kite import of axicabtagene ciloleucel became China's first CAR-T approval; relapsed or refractory follicular lymphoma followed in 2022. The pivotal RELIANCE study (59 patients) reported an objective response rate of 75.9% and complete responses in 51.7%, with low rates of severe cytokine release syndrome. JW Therapeutics was formed in 2016 as a joint venture between Juno Therapeutics and WuXi AppTec, and the product is the Chinese sibling of lisocabtagene maraleucel.
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Approvals
| Region | Year | Indication |
|---|---|---|
| China | 2021 | Relapsed or refractory large B-cell lymphoma after two or more lines |
| China | 2022 | Relapsed or refractory follicular lymphoma after two or more lines |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Relmacabtagene autoleucel" OR ABSTRACT:"Relmacabtagene autoleucel" OR TITLE:"Carteyva" OR ABSTRACT:"Carteyva" OR TITLE:"relma-cel" OR ABSTRACT:"relma-cel" OR TITLE:"JWCAR029" OR ABSTRACT:"JWCAR029") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Relmacabtagene autoleucel, not a curated reading list.
Pages like this
not linked directly; found by shared links- PersonGe Li
Shares WuXi AppTec, JW Therapeutics and the tag china.
- ProductInaticabtagene autoleucel
Shares CD19, CAR-T cell therapy and the tag china.
- CompanyWuXi Biologics
Shares WuXi AppTec and the tag china.
- InstitutionPeking University People's Hospital
Shares CAR-T cell therapy and the tag china.
- TrialLUMMICAR STUDY 1
Shares CAR-T cell therapy and the tag china.
- InstitutionInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences
Shares CAR-T cell therapy and the tag china.
- CompanyIASO Biotherapeutics
Shares CAR-T cell therapy and the tag china.
- InstitutionRenji Hospital, Shanghai Jiao Tong University
Shares CAR-T cell therapy and the tag china.