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STAR-LLD is lenalidomide, an established myeloma medicine, given continuously at a low dose through a small pump under the skin or a slow-release tablet. Starton Holdings is testing it in multiple myeloma that has come back after earlier treatment.
STAR-LLD is Starton Holdings' name for its continuous low-dose lenalidomide product candidates: STAR-LLD-SC, a patented subcutaneous formulation given by ambulatory pump, and STAR-LLD-OCR, an oral controlled-release formulation. Starton's 2026 S-1 states that Phase 1 and 1b studies of STAR-LLD-SC in multiple myeloma are complete and that a Phase 2a study is under way in relapsed or refractory multiple myeloma, in patients receiving a triplet of a proteasome inhibitor, dexamethasone and continuously infused lenalidomide. Investigator-initiated trials with CAR-T cell therapies and T-cell engagers are planned, the first combining STAR-LLD with elranatamab in relapsed or refractory multiple myeloma. The reference listed drug is Revlimid, and the company intends to use the 505(b)(2) pathway. The registered trial NCT06087653, sponsored by Starton Therapeutics, tests continuous subcutaneous low-dose lenalidomide in multiple myeloma.
Lenalidomide, the active ingredient of Revlimid, given continuously at low dose by subcutaneous ambulatory pump or as an oral controlled-release tablet, intended to lower the peak blood concentration and overall exposure and so improve tolerability, as Starton's filing describes it.
1.STAR-LLD slips into a pocket on its target.
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Query for this drug: (TITLE:"STAR-LLD" OR ABSTRACT:"STAR-LLD" OR TITLE:"STAR-LLD-SC" OR ABSTRACT:"STAR-LLD-SC" OR TITLE:"STAR-LLD-OCR" OR ABSTRACT:"STAR-LLD-OCR" OR TITLE:"continuous low-dose lenalidomide" OR ABSTRACT:"continuous low-dose lenalidomide") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STAR-LLD, not a curated reading list.
Shares Lenalidomide, Multiple myeloma and the tag pipeline.
Shares Multiple myeloma and the tag pipeline.
Shares Lenalidomide and the tag pipeline.
Shares Multiple myeloma and the tag pipeline.
Shares Multiple myeloma and the tag pipeline.
Shares Multiple myeloma and the tag pipeline.
Shares Multiple myeloma and the tag pipeline.
Shares Multiple myeloma and the tag pipeline.
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