STX-0712 is an experimental cyTAC with ADCC-enhanced platform antibody from Solu Therapeutics, in phase 1 trials for chronic myelomonocytic leukaemia and acute myeloid leukaemia.
STX-0712 is a cyTAC (cytotoxicity targeting chimera) with ADCC-enhanced platform antibody from Solu Therapeutics. A CyTAC targeting the GPCR CCR2, a marker expressed at high levels on pathogenic monocytes, designed to eliminate those cells. Its furthest stage is phase 1, for chronic myelomonocytic leukaemia and acute myeloid leukaemia. ClinicalTrials.gov registers it in one study linked below. Phase 1 NCT06950034 recruiting, title includes CMML and AML (registry, 3 Nov 2026). Whether it works in people has not been established unless a trial below reports it.
A CyTAC targeting the GPCR CCR2, a marker expressed at high levels on pathogenic monocytes, designed to eliminate those cells.
1.STX-0712 binds its target.
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Query for this drug: (TITLE:"STX-0712" OR ABSTRACT:"STX-0712") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STX-0712, not a curated reading list.
Shares Solu Therapeutics and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
Shares Acute myeloid leukaemia and the tag pipeline.
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