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CBX-250 is an experimental TCR-mimetic T cell engager from Crossbow Therapeutics, in phase 1 trials for relapsed or refractory acute myeloid leukaemia, higher-risk myelodysplastic syndrome and chronic myelomonocytic leukaemia and other cancers.
CBX-250 is a TCR-mimetic T cell engager (T-Bolt) from Crossbow Therapeutics. A T cell engager whose TCR-mimetic antibody arm recognises a cathepsin G peptide presented on HLA, abundant on leukaemia cells but not normal cells, and pulls T cells onto them. Given under the skin. Its furthest stage is phase 1, for relapsed or refractory acute myeloid leukaemia, higher-risk myelodysplastic syndrome, chronic myelomonocytic leukaemia and chronic myeloid leukaemia. ClinicalTrials.gov registers it in one study linked below. CROSSCHECK-001 phase 1 NCT06994676 recruiting. Whether it works in people has not been established unless a trial below reports it.
A T cell engager whose TCR-mimetic antibody arm recognises a cathepsin G peptide presented on HLA, abundant on leukaemia cells but not normal cells, and pulls T cells onto them. Given under the skin.
1.One arm of CBX-250 binds its target on the cancer cell.
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Query for this drug: (TITLE:"CBX-250" OR ABSTRACT:"CBX-250") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CBX-250, not a curated reading list.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Acute myeloid leukaemia and the tag pipeline.
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