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AMX-883 is an experimental oral small-molecule targeted protein degrader from Amphista Therapeutics, in phase 1 trials for acute myeloid leukaemia and higher-risk myelodysplastic syndromes.
AMX-883 is an oral small-molecule targeted protein degrader (Targeted Glue) from Amphista Therapeutics. An oral degrader that uses the E3 ligase DCAF16 to destroy BRD9; in preclinical work this released the differentiation block in a broad range of AML models and was synergistic with venetoclax. Its furthest stage is phase 1, for acute myeloid leukaemia and higher-risk myelodysplastic syndromes. ClinicalTrials.gov registers it in one study linked below. FDA cleared the IND; phase 1 NCT07723703 recruiting. Whether it works in people has not been established unless a trial below reports it.
An oral degrader that uses the E3 ligase DCAF16 to destroy BRD9; in preclinical work this released the differentiation block in a broad range of AML models and was synergistic with venetoclax.
1.AMX-883 binds its target with one end and an E3 ubiquitin ligase with the other.
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Query for this drug: (TITLE:"AMX-883" OR ABSTRACT:"AMX-883") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AMX-883, not a curated reading list.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes, Acute myeloid leukaemia and the tag pipeline.
Shares Higher-risk myelodysplastic syndromes and the tag pipeline.
Shares Acute myeloid leukaemia and the tag pipeline.
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