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TUB-030 is an experimental antibody-drug conjugate from Tubulis (Gilead), in phase 1 trials for advanced solid tumours, head and neck squamous cell carcinoma and small cell lung cancer and other cancers.
TUB-030 is an antibody-drug conjugate from Tubulis (Gilead), with Gilead Sciences as acquirer. An IgG1 antibody against 5T4 joined to the topoisomerase I inhibitor exatecan through a cleavable linker made with P5 conjugation, with a drug-to-antibody ratio of 8. Its furthest stage is phase 1, for advanced solid tumours, head and neck squamous cell carcinoma, small cell lung cancer and non-small cell lung cancer. ClinicalTrials.gov registers it in one study linked below. Tubulis pipeline page: Phase I/IIa study 5-STAR 1-01 (NCT06657222), status shown as Phase 1; recruiting per registry. Whether it works in people has not been established unless a trial below reports it.
An IgG1 antibody against 5T4 joined to the topoisomerase I inhibitor exatecan through a cleavable linker made with P5 conjugation, with a drug-to-antibody ratio of 8.
1.TUB-030's antibody arm binds its target on the surface of the cancer cell.
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Query for this drug: (TITLE:"TUB-030" OR ABSTRACT:"TUB-030") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUB-030, not a curated reading list.
Shares Tubulis (Gilead), Non-small-cell lung cancer and the tag pipeline.
Shares Tubulis (Gilead) and the tag pipeline.
Shares Tubulis (Gilead) and the tag pipeline.
Shares Small-cell lung cancer, Triple-negative breast cancer (TNBC), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Small-cell lung cancer, Triple-negative breast cancer (TNBC), Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Small-cell lung cancer, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares Triple-negative breast cancer (TNBC), Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Small-cell lung cancer, Non-small-cell lung cancer and the tag pipeline.
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