Deliver CAR-T cells straight into the fluid around the brain
Cancer spreading along the linings of the brain is almost untreatable. Injecting engineered immune cells directly into the brain fluid, through a small reservoir, reaches it.
Intraventricular delivery of HER2-directed CAR-T cells via an Ommaya reservoir has produced responses in leptomeningeal metastasis in early trials at City of Hope, and intrathecal chemotherapy is long-established. Local delivery avoids the barrier entirely, gives high local cell dose and appears to reduce systemic cytokine toxicity.
- The brain: barrier and sanctuary · Most drugs cannot cross into the brain, so brain tumours and brain metastases lag every other site.
- Metastasis is understood least and studied last · Metastasis causes about nine in ten cancer deaths but gets a small fraction of research money and almost no trials of its own.
Pages like this
not linked directly; found by shared links- IdeaOpen the barrier so engineered immune cells can enter the brain
Shares CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target), B7-H3, The brain: barrier and sanctuary, Glioma & glioblastoma.
- PersonBehnam Badie
Shares City of Hope, Glioma & glioblastoma, CAR-T cell therapy.
- PersonChristine E. Brown
Shares City of Hope, Glioma & glioblastoma, CAR-T cell therapy.
- TrialDESTINY-Breast12
Shares HER2-positive brain metastases, The brain: barrier and sanctuary, HER2-positive breast cancer.
- IdeaA standard platform to get drugs into the brain: focused ultrasound plus shuttle-engineered therapeutics
Shares The brain: barrier and sanctuary, Metastasis is understood least and studied last, HER2-positive breast cancer, Glioma & glioblastoma.
- ProductNeratinib
Shares HER2-positive brain metastases, HER2, HER2-positive breast cancer.
- CompanyDuality Biotherapeutics
- IdeaUse the brain's own transport door to carry antibody drugs across
Shares HER2-positive brain metastases, The brain: barrier and sanctuary, HER2, HER2-positive breast cancer.