A global rapid tissue donation network for metastatic disease
Almost all cancer deaths are caused by spread, yet very little spread tissue is ever studied. A network collecting donated tissue within hours of death would change that.
Rapid autopsy programmes at a handful of centres have produced disproportionate insight into metastatic evolution and treatment resistance, but they are small, precariously funded and not interoperable. A funded 20-site network with a shared protocol, single consent framework, common data commons and open sample access would industrialise the most information-dense sample type in oncology.
- Metastasis is understood least and studied last · Metastasis causes about nine in ten cancer deaths but gets a small fraction of research money and almost no trials of its own.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
- Data silos · Records, scans, genomes and outcomes sit in separate systems that cannot talk. Every patient's experience is lost to the next.
Pages like this
not linked directly; found by shared links- IdeaLet patients themselves donate their records and samples for ultra-rare cancers
Shares cBioPortal for Cancer Genomics, AACR Project GENIE, Whole-exome & whole-genome sequencing, Data silos.
- IdeaAn organotropism atlas that predicts where a cancer will spread
Shares cBioPortal for Cancer Genomics, AACR Project GENIE, Metastasis is understood least and studied last, Data silos.
- InstitutionWellcome
Shares Charles Swanton, Single-cell & spatial profiling, Whole-exome & whole-genome sequencing, Data silos.
- IdeaLink single-cell and spatial tumour atlases to clinical outcomes
Shares TCGA / NCI Genomic Data Commons, Single-cell & spatial profiling, Data silos.
- IdeaPool every immunotherapy trial's biomarker data into one commons
Shares cBioPortal for Cancer Genomics, AACR Project GENIE, Single-cell & spatial profiling, Data silos.
- CompanyElucidate Bio
Shares Proteomics & phosphoproteomics, Single-cell & spatial profiling.
- IdeaA national rapid research autopsy network for end-stage cancer
Shares Single-cell & spatial profiling, Metastasis is understood least and studied last, Whole-exome & whole-genome sequencing.
- IdeaLink every national cancer registry to tumour genomics
Shares AACR Project GENIE, Whole-exome & whole-genome sequencing, Data silos.