ctHPV-DNA-adapted de-escalation of chemoradiation
Instead of guessing from HPV status who can get less radiation, measure the virus DNA in blood during treatment and reduce dose only when it clears fast.
HN005 showed static selection fails. Early clearance of ctHPV-DNA during induction or the first weeks of radiation identifies exceptional responders. Several phase 2 trials (including neoadjuvant chemotherapy with response-adapted radiation) are testing dynamic selection.
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