Offer the blood test for bowel cancer only to people who refuse stool tests or colonoscopy
Blood tests for bowel cancer miss most precancerous polyps, so they should not replace stool tests. But for the third of people who never do any screening, a blood test may beat nothing.
Shield (Guardant) is FDA-approved with about 83% sensitivity for colorectal cancer but around 13% for advanced adenomas; the concern is substitution away from FIT and colonoscopy. Propose a randomised trial in persistent non-responders: blood test offer versus repeat FIT offer, endpoint stage I-II cancers detected per 1,000 invited.
- Most lethal cancers are found late · Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely.
- Prevention we already have is not deployed · Around four in ten cancers are preventable with tools we already own: vaccines, tobacco control, weight, alcohol, sun and infection control.
Pages like this
not linked directly; found by shared links- IdeaMandatory interval-cancer audit for every blood-based screening test
Shares Shield, Most lethal cancers are found late, Liquid biopsy (ctDNA).
- IdeaMake a two-minute mouth cancer check part of every dental visit
Shares Prevention we already have is not deployed, Most lethal cancers are found late.
- IdeaA single 'cancer check at 60' appointment bundling all screening tests
Shares Prevention we already have is not deployed, Most lethal cancers are found late.
- PersonKatie Couric
Shares Prevention we already have is not deployed, Most lethal cancers are found late, Colorectal cancer.
- IdeaA swallowable sponge test for reflux patients, offered in pharmacies
Shares Prevention we already have is not deployed, Most lethal cancers are found late.
- IdeaUse tumour DNA in blood to decide when to pause treatment in metastatic cancer
Shares Guardant Health, Liquid biopsy (ctDNA), Colorectal cancer.
- IdeaDrop mandatory fresh biopsies where blood or archival tissue would do
Shares Guardant Health, Liquid biopsy (ctDNA).
- Key paperMinnesota trial: a yearly stool blood test cuts bowel cancer deaths by a third
Shares Prevention we already have is not deployed, Most lethal cancers are found late, Colorectal cancer.