Early detection of cancer
Paper cited by one bottleneck page and 32 idea pages, indexed on Europe PMC as PubMed record 35298272 and published in Science; the citing pages link this DOI, which is how the record was matched.
Overview
Survival improves when cancer is detected early. However, ~50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome. It is vital to better understand who is at greatest risk of developing cancer. We also need to elucidate the biology and trajectory of precancer and early cancer to identify consequential disease that requires intervention. Insights must be translated into sensitive and specific early detection technologies and be appropriately evaluated to support practical clinical implementation. Interdisciplinary collaboration is key; advances in technology and biological understanding highlight that it is time to accelerate early detection research and transform cancer survival.
Indexed on Europe PMC as PubMed record 35298272 (DOI 10.1126/science.aay9040). Matched by DOI alone: one bottleneck page and 32 idea pages cite this DOI among their external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.
One bottleneck page and 32 idea pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.
Similar pages
not linked directly; found by shared links- TermPositive predictive value (PPV)
Shares A breath test to rule out cancer in people with vague symptoms, Multi-cancer blood test as the first step for patients with non-specific symptoms, A urine DNA test to decide who with blood in the urine needs a camera test, A 28-day national pathway for people with a positive multi-cancer blood test.
- TechnologyMulti-cancer early detection (MCED)
Shares A cancer blood test for older people arriving at A&E with unexplained symptoms, Cheap DNA fragment-pattern blood test as a first sieve before expensive cancer tests, Multi-cancer blood test as the first step for patients with non-specific symptoms, Registry-based randomised MCED trial: a million people, no study visits.
- TreatmentGalleri
Shares Multi-cancer blood test as the first step for patients with non-specific symptoms, Mandatory interval-cancer audit for every blood-based screening test, A whole-population cancer interception programme: risk-stratify every adult, detect and intercept early, The hardest cancers are found late.
- CompanyGRAIL
Shares Multi-cancer blood test as the first step for patients with non-specific symptoms, Pre-agreed update rules so an MCED test is not obsolete when its trial reads out, The hardest cancers are found late.
- IdeaFAPI PET as the workup for MCED positives
Shares A 28-day national pathway for people with a positive multi-cancer blood test, A whole-population cancer interception programme: risk-stratify every adult, detect and intercept early, The hardest cancers are found late.
- Key paperNLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers
Shares Take lung screening scanners to supermarket car parks in the poorest areas, Lung screening eligibility by risk score, not pack-years, including high-risk never-smokers, The hardest cancers are found late.
- TechnologyCT (computed tomography)
Shares Take lung screening scanners to supermarket car parks in the poorest areas, AI that spots pancreatic cancer on scans taken a year before diagnosis, Lung screening eligibility by risk score, not pack-years, including high-risk never-smokers, New diabetes after 50 plus weight loss triggers a pancreatic cancer check.
- TermStage shift
Shares A live national dashboard of stage at diagnosis as the scorecard for early detection, Registry-based randomised MCED trial: a million people, no study visits, A whole-population cancer interception programme: risk-stratify every adult, detect and intercept early, The hardest cancers are found late.