Barbara Ann Karmanos Cancer Institute
Detroit's NCI comprehensive cancer centre, where the MCF-7 breast cancer cell line was derived in 1973, now part of McLaren Health Care.
Karmanos descends from the Michigan Cancer Foundation, where in 1973 Herbert Soule derived MCF-7, the oestrogen-receptor-positive breast cancer cell line that became the most studied cancer cell model in the world. NCI-designated since 1978, it is Wayne State University's cancer centre and, since 2014, part of McLaren Health Care, giving it a statewide network of cancer sites across Michigan. It has long run one of the larger academic phase 1 programmes and studies cancer in Detroit's predominantly Black population. Karmanos also operates the Detroit metropolitan SEER registry.
- Phase 1 trials
- Breast cancer biology (MCF-7 heritage)
- Population science (Detroit SEER)
Pages like this
not linked directly; found by shared links- ProductGoserelin / leuprolide (ovarian function suppression)
Shares Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- IdeaLow-dose tamoxifen for high-risk women, prescribed by pharmacists and nurses
Shares Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- IdeaPost-marketing safety monitoring stratified by ancestry and sex, with label updates
Shares Trials do not represent the people who get cancer, Real-world evidence.
- TriallidERA
Shares Estrogen receptor (ERα), HR-positive / HER2-negative breast cancer.
- ProductExemestane
Shares Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- IdeaMandatory real-world reporting for patients excluded from pivotal trials
Shares Trials do not represent the people who get cancer, Real-world evidence.
- PersonAnn H. Partridge
Shares Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- InstitutionVCU Massey Comprehensive Cancer Center
Shares Trials do not represent the people who get cancer, Real-world evidence.