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Looking at cells grown from an African child's jaw tumour under an electron microscope, three researchers in London saw virus particles, the first virus ever linked to a human cancer.
Michael Anthony Epstein, Bert Achong and Yvonne Barr reported virus particles in lymphoblasts cultured from a Burkitt lymphoma biopsy. Europe PMC indexes no abstract for the Lancet report, so no figure from it is quoted here.
Its importance is categorical rather than numerical: it was the first demonstration of a virus in a human tumour, and it opened the field that now includes human papillomavirus and cervical cancer, hepatitis B and C and liver cancer, Helicobacter pylori and gastric MALT lymphoma, human herpesvirus 8 and Kaposi sarcoma and primary effusion lymphoma, and human T-lymphotropic virus type 1 and adult T-cell leukaemia/lymphoma.
Epstein-Barr virus is now known to infect most of the world's adult population harmlessly and to be associated with endemic Burkitt lymphoma, a subset of Hodgkin lymphoma, Epstein-Barr virus-positive diffuse large B-cell lymphoma, extranodal NK/T-cell lymphoma, post-transplant lymphoproliferative disorder and nasopharyngeal carcinoma. Two companion papers from the same group appeared in the same year, on the cultivation of the lymphoblasts (PubMed 14090852) and on a second virus-carrying strain (PubMed 14255814).
The start of viral oncology. Everything in cancer prevention that works by preventing or treating an infection, from hepatitis B vaccination to Helicobacter eradication for gastric MALT lymphoma, descends from the idea this paper established.
Shares A sarcoma involving the jaws in African children, Burkitt lymphoma, Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting, Most of the world has almost no cancer care and the tag lymphoma-evidence.
Shares Prevention we already have is not deployed, Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting, Most of the world has almost no cancer care, Non-Hodgkin lymphoma (all types) and the tag lymphoma-evidence.
Shares Prevention we already have is not deployed, Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting, Most of the world has almost no cancer care, Non-Hodgkin lymphoma (all types) and the tag lymphoma-evidence.
Shares The Lancet, Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting, Non-Hodgkin lymphoma (all types) and the tag lymphoma-evidence.
Shares The Lancet, Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting, Non-Hodgkin lymphoma (all types) and the tag lymphoma-evidence.
Shares The Lancet, Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting, Non-Hodgkin lymphoma (all types) and the tag lymphoma-evidence.
Shares Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting, Most of the world has almost no cancer care, Non-Hodgkin lymphoma (all types) and the tag lymphoma-evidence.
Shares Lymphoma roadmap: from a jaw tumour in Uganda and the first human cancer virus to gene-expression subtypes, PET-adapted chemotherapy, CAR-T cells, bispecific antibodies and the genetics-directed trials now recruiting, Most of the world has almost no cancer care, Non-Hodgkin lymphoma (all types) and the tag lymphoma-evidence.