Management of incidental gallbladder cancer in the nationwide CAPBIL study
The first UK-wide picture of gallbladder cancers found by chance: across 24 centres over nine years, two thirds went on to liver surgery and those who did stayed free of disease far longer.
Overview
UK HPB Research Collaborative Group study of 285 patients diagnosed with incidental gallbladder cancer after cholecystectomy between January 2014 and December 2022 at 24 UK centres. Median follow-up was 31 months; five-year disease-free survival was 41.5 percent and overall survival 45.1 percent. Of 193 patients (67.7 percent) who underwent liver resection, 97.9 percent had segment 4b/5 resection. Liver resection was associated with longer disease-free survival (51 versus 15 months). Adverse tumour biology was associated with poorer survival.
- 285 incidental gallbladder cancers at 24 UK centres, 2014 to 2022; five-year disease-free survival 41.5 percent, overall survival 45.1 percent.
- 193 patients (67.7 percent) underwent liver resection, 97.9 percent of them segment 4b/5.
- Median disease-free survival 51 months with liver resection vs 15 months without.
This is the UK baseline for the incidental cancer pathway: a re-resection rate well above the Dutch registry's 24 percent, with the same selection caveat. The UK layer of this deep dive should read the full paper for the histology, referral and timing detail the abstract leaves out.
- Retrospective, unmatched comparison; patients not offered surgery were likely sicker or more advanced.
- Abstract reports disease-free survival months without confidence intervals.
Similar pages
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