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A method that reads DNA methylation in blood to measure metastatic breast cancer and call its oestrogen receptor status without tumour tissue.
METER exploits tumour-type-specific DNA methylation patterns for ctDNA detection, quantification and subtyping from plasma low-pass (0.5 to 1x) whole-methylome sequencing. In longitudinal samples from metastatic breast cancer it showed a stronger association with clinical outcomes than other ctDNA methods and matched circulating tumour cell counts, even at tumour content below 3 per cent. In the full text, oestrogen receptor calls in samples with at least 5 per cent tumour content reached an accuracy of 0.93 (95% CI 0.85 to 0.97) when the MIMESIS-1 and MIMESIS-2 cohorts were combined.
Methylation in blood can say whether advanced breast cancer still carries the oestrogen receptor. Subtyping still needs percent-level tumour content.
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, Cell-free DNA (cfDNA), Estrogen receptor (ERα), Circulating tumour DNA (ctDNA).
Shares METER (methylome-based ctDNA detection and subtyping), Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, Cell-free DNA (cfDNA), Estrogen receptor (ERα).
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, DNA methylation profiling, Circulating tumour DNA (ctDNA).
Shares Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA).
Shares Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA).
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, DNA methylation profiling.
Shares Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA).
Shares Read methylation and mutation on the same cell-free DNA fragment to tell what kind of cancer is left, Circulating tumour DNA (ctDNA).
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